Protein name:
Lysosomal acid lipase/cholesteryl ester hydrolase (Acid cholesteryl ester hydrolase;LAL) ;
Alternative:
Lipase A ;Cholesteryl esterase ;Sterol esterase ;
Organism:
Human (Homo sapiens).
General Annotation
Function:
Crucial for the intracellular hydrolysis of cholesteryl esters and triglycerides that have been internalized via receptor-mediated endocytosis of lipoprotein particles. Important in mediating the effect of LDL (low density lipoprotein) uptake on suppression of hydroxymethylglutaryl-CoA reductase and activation of endogenous cellular cholesteryl ester formation.
Subcellular Location:
Lysosome
Protein Attributes:
50:
MKMRFLGLVV | CLVLWTLHSE | GSGGKLTAVD | PETNMNVSEI | ISYWGFPSEE |
100:
YLVETEDGYI | LCLNRIPHGR | KNHSDKGPKP | VVFLQHGLLA | DSSNWVTNLA |
150:
NSSLGFILAD | AGFDVWMGNS | RGNTWSRKHK | TLSVSQDEFW | AFSYDEMAKY |
200:
DLPASINFIL | NKTGQEQVYY | VGHSQGTTIG | FIAFSQIPEL | AKRIKMFFAL |
250:
GPVASVAFCT | SPMAKLGRLP | DHLIKDLFGD | KEFLPQSAFL | KWLGTHVCTH |
300:
VILKELCGNL | CFLLCGFNER | NLNMSRVDVY | TTHSPAGTSV | QNMLHWSQAV |
350:
KFQKFQAFDW | GSSAKNYFHY | NQSYPPTYNV | KDMLVPTAVW | SGGHDWLADV |
399:
YDVNILLTQI | TNLVFHESIP | EWEHLDFIWG | LDAPWRLYNK | IINLMRKYQ
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Mouse
Human
Rat
ELISA Kit for Human Acid cholesteryl ester hydrolase
ELISA Kit for Human Acid cholesteryl ester hydrolase
ELISA Kit for Human Acid cholesteryl ester hydrolase
CLIA Kit for Human Acid cholesteryl ester hydrolase
CLIA Kit for Human Acid cholesteryl ester hydrolase
CLIA Kit for Human Acid cholesteryl ester hydrolase
Polyclonal Antibody for Human Acid cholesteryl ester hydrolase
Polyclonal Antibody for Human Acid cholesteryl ester hydrolase
Polyclonal Antibody for Human Acid cholesteryl ester hydrolase
Monoclonal Antibody for Human Acid cholesteryl ester hydrolase
Monoclonal Antibody for Human Acid cholesteryl ester hydrolase
Monoclonal Antibody for Human Acid cholesteryl ester hydrolase
Protein for Human Acid cholesteryl ester hydrolase
Protein for Human Acid cholesteryl ester hydrolase
Protein for Human Acid cholesteryl ester hydrolase
R&D Technical Data
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
Precision
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
Recovery
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
Linearity
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);PROTEIN SEQUENCE OF 196-212; 277-297 AND 305-315;VARIANT PRO-16
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
tissue :
Liver .
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANT ARG-23
tissue :
Liver .
4.
"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T.
,
Suzuki Y.
,
Nishikawa T.
,
Otsuki T.
,
Sugiyama T.
,
Irie R.
,
Wakamatsu A.
,
Hayashi K.
,
Sato H.
,
Nagai K.
,
Kimura K.
,
Makita H.
,
Sekine M.
,
Obayashi M.
,
Nishi T.
,
Shibahara T.
,
Tanaka T.
,
Ishii S.
,
Yamamoto J.
,
Saito K.
,
Kawai Y.
,
Isono Y.
,
Nakamura Y.
,
Nagahari K.
,
Murakami K.
,
Yasuda T.
,
Iwayanagi T.
,
Wagatsuma M.
,
Shiratori A.
,
Sudo H.
,
Hosoiri T.
,
Kaku Y.
,
Kodaira H.
,
Kondo H.
,
Sugawara M.
,
Takahashi M.
,
Kanda K.
,
Yokoi T.
,
Furuya T.
,
Kikkawa E.
,
Omura Y.
,
Abe K.
,
Kamihara K.
,
Katsuta N.
,
Sato K.
,
Tanikawa M.
,
Yamazaki M.
,
Ninomiya K.
,
Ishibashi T.
,
Yamashita H.
,
Murakawa K.
,
Fujimori K.
,
Tanai H.
,
Kimata M.
,
Watanabe M.
,
Hiraoka S.
,
Chiba Y.
,
Ishida S.
,
Ono Y.
,
Takiguchi S.
,
Watanabe S.
,
Yosida M.
,
Hotuta T.
,
Kusano J.
,
Kanehori K.
,
Takahashi-Fujii A.
,
Hara H.
,
Tanase T.-O.
,
Nomura Y.
,
Togiya S.
,
Komai F.
,
Hara R.
,
Takeuchi K.
,
Arita M.
,
Imose N.
,
Musashino K.
,
Yuuki H.
,
Oshima A.
,
Sasaki N.
,
Aotsuka S.
,
Yoshikawa Y.
,
Matsunawa H.
,
Ichihara T.
,
Shiohata N.
,
Sano S.
,
Moriya S.
,
Momiyama H.
,
Satoh N.
,
Takami S.
,
Terashima Y.
,
Suzuki O.
,
Nakagawa S.
,
Senoh A.
,
Mizoguchi H.
,
Goto Y.
,
Shimizu F.
,
Wakebe H.
,
Hishigaki H.
,
Watanabe T.
,
Sugiyama A.
,
Takemoto M.
,
Kawakami B.
,
Yamazaki M.
,
Watanabe K.
,
Kumagai A.
,
Itakura S.
,
Fukuzumi Y.
,
Fujimori Y.
,
Komiyama M.
,
Tashiro H.
,
Tanigami A.
,
Fujiwara T.
,
Ono T.
,
Yamada K.
,
Fujii Y.
,
Ozaki K.
,
Hirao M.
,
Ohmori Y.
,
Kawabata A.
,
Hikiji T.
,
Kobatake N.
,
Inagaki H.
,
Ikema Y.
,
Okamoto S.
,
Okitani R.
,
Kawakami T.
,
Noguchi S.
,
Itoh T.
,
Shigeta K.
,
Senba T.
,
Matsumura K.
,
Nakajima Y.
,
Mizuno T.
,
Morinaga M.
,
Sasaki M.
,
Togashi T.
,
Oyama M.
,
Hata H.
,
Watanabe M.
,
Komatsu T.
,
Mizushima-Sugano J.
,
Satoh T.
,
Shirai Y.
,
Takahashi Y.
,
Nakagawa K.
,
Okumura K.
,
Nagase T.
,
Nomura N.
,
Kikuchi H.
,
Masuho Y.
,
Yamashita R.
,
Nakai K.
,
Yada T.
,
Nakamura Y.
,
Ohara O.
,
Isogai T.
,
Sugano S.
more...
Nat. Genet.36:40-45(2004)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANT PRO-16
tissue :
Umbilical cord blood .
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue :
Liver .
6.
"The DNA sequence and comparative analysis of human chromosome 10."
Deloukas P.
,
Earthrowl M.E.
,
Grafham D.V.
,
Rubenfield M.
,
French L.
,
Steward C.A.
,
Sims S.K.
,
Jones M.C.
,
Searle S.
,
Scott C.
,
Howe K.
,
Hunt S.E.
,
Andrews T.D.
,
Gilbert J.G.R.
,
Swarbreck D.
,
Ashurst J.L.
,
Taylor A.
,
Battles J.
,
Bird C.P.
,
Ainscough R.
,
Almeida J.P.
,
Ashwell R.I.S.
,
Ambrose K.D.
,
Babbage A.K.
,
Bagguley C.L.
,
Bailey J.
,
Banerjee R.
,
Bates K.
,
Beasley H.
,
Bray-Allen S.
,
Brown A.J.
,
Brown J.Y.
,
Burford D.C.
,
Burrill W.
,
Burton J.
,
Cahill P.
,
Camire D.
,
Carter N.P.
,
Chapman J.C.
,
Clark S.Y.
,
Clarke G.
,
Clee C.M.
,
Clegg S.
,
Corby N.
,
Coulson A.
,
Dhami P.
,
Dutta I.
,
Dunn M.
,
Faulkner L.
,
Frankish A.
,
Frankland J.A.
,
Garner P.
,
Garnett J.
,
Gribble S.
,
Griffiths C.
,
Grocock R.
,
Gustafson E.
,
Hammond S.
,
Harley J.L.
,
Hart E.
,
Heath P.D.
,
Ho T.P.
,
Hopkins B.
,
Horne J.
,
Howden P.J.
,
Huckle E.
,
Hynds C.
,
Johnson C.
,
Johnson D.
,
Kana A.
,
Kay M.
,
Kimberley A.M.
,
Kershaw J.K.
,
Kokkinaki M.
,
Laird G.K.
,
Lawlor S.
,
Lee H.M.
,
Leongamornlert D.A.
,
Laird G.
,
Lloyd C.
,
Lloyd D.M.
,
Loveland J.
,
Lovell J.
,
McLaren S.
,
McLay K.E.
,
McMurray A.
,
Mashreghi-Mohammadi M.
,
Matthews L.
,
Milne S.
,
Nickerson T.
,
Nguyen M.
,
Overton-Larty E.
,
Palmer S.A.
,
Pearce A.V.
,
Peck A.I.
,
Pelan S.
,
Phillimore B.
,
Porter K.
,
Rice C.M.
,
Rogosin A.
,
Ross M.T.
,
Sarafidou T.
,
Sehra H.K.
,
Shownkeen R.
,
Skuce C.D.
,
Smith M.
,
Standring L.
,
Sycamore N.
,
Tester J.
,
Thorpe A.
,
Torcasso W.
,
Tracey A.
,
Tromans A.
,
Tsolas J.
,
Wall M.
,
Walsh J.
,
Wang H.
,
Weinstock K.
,
West A.P.
,
Willey D.L.
,
Whitehead S.L.
,
Wilming L.
,
Wray P.W.
,
Young L.
,
Chen Y.
,
Lovering R.C.
,
Moschonas N.K.
,
Siebert R.
,
Fechtel K.
,
Bentley D.
,
Durbin R.M.
,
Hubbard T.
,
Doucette-Stamm L.
,
Beck S.
,
Smith D.R.
,
Rogers J.
more...
Nature429:375-381(2004)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
7.
Mural R.J.
,
Istrail S.
,
Sutton G.G.
,
Florea L.
,
Halpern A.L.
,
Mobarry C.M.
,
Lippert R.
,
Walenz B.
,
Shatkay H.
,
Dew I.
,
Miller J.R.
,
Flanigan M.J.
,
Edwards N.J.
,
Bolanos R.
,
Fasulo D.
,
Halldorsson B.V.
,
Hannenhalli S.
,
Turner R.
,
Yooseph S.
,
Lu F.
,
Nusskern D.R.
,
Shue B.C.
,
Zheng X.H.
,
Zhong F.
,
Delcher A.L.
,
Huson D.H.
,
Kravitz S.A.
,
Mouchard L.
,
Reinert K.
,
Remington K.A.
,
Clark A.G.
,
Waterman M.S.
,
Eichler E.E.
,
Adams M.D.
,
Hunkapiller M.W.
,
Myers E.W.
,
Venter J.C.
more...
Submitted (2005-09) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANTS PRO-16 AND LEU-29
tissue :
Placenta .
9.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-161 AND ASN-321
tissue :
Liver .
10.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
11.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANT CESD/WOD PRO-200
12.
"Different missense mutations in histidine-108 of lysosomal acid lipase cause cholesteryl ester storage disease in unrelated compound heterozygous and hemizygous individuals."
Ries S.
,
Buechler C.
,
Schindler G.
,
Aslanidis C.
,
Ameis D.
,
Gasche C.
,
Jung N.
,
Schambach A.
,
Fehringer P.
,
Vanier M.T.
,
Belli D.C.
,
Greten H.
,
Schmitz G.
Hum. Mutat.12:44-51(1998)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANTS CESD ARG-129 AND PRO-129